Archives

xMAP®-powered Assay Provides Critical Clues from Liquid Biopsy Samples

3月 5th, 2019 / Hilary Graham

14-gene assay interrogates circulating tumor cells Liquid biopsies are opening new avenues for cancer research

Continue reading »

Meet Ankit Patel, QuantiGene™ Assay Developer at Thermo Fisher Scientific

3月 26th, 2019 / Hilary Graham

Plus: 6 tips for QuantiGene assays When you want an assay that can detect nucleic acids, you’ll likely choose

Continue reading »

5 Tips for Multiplex Kit Users and Assay Developers

11月 21st, 2017 / Hilary Graham

Woei Tan, PhD, is a Senior Staff Scientist at Bio-Rad Laboratories in the San Francisco Bay Area. Tan shares a

Continue reading »

Protagen is Taking Biomarkers from the Bench to the Bedside

9月 19th, 2017 / Hilary Graham

The FLEXMAP 3D® supports high-throughput discovery of autoantibody biomarker candidates Peter Schulz-Knappe is

Continue reading »

Tips and Tricks from Luminex Tech Support

10月 11th, 2016 / Hilary Graham

Tip #1: Frustrated by verification failure?

Some MAGPIX® verification failures are the result of debris on the chamber or clogs in the sample probe and in the sample lines. As the composition of the debris is generally unknown, running the Enhanced Startup routine twice…

Tip #2: Getting an error code?

The most common instrument code is 800C9580. This is a system code, not an error code, and will accompany both MAGPIX® and LXR (Luminex® 200 and FLEXMAP 3D®) error codes…

Continue reading »

Partner Product Offerings: Bio-Rad | Millipore Sigma | Affymetrix | R&D Systems

5月 23rd, 2017 / Hilary Graham

There are currently more than 60 Luminex Licensed Technologies Partners worldwide that provide kits, assay dev

Continue reading »

PRISM: A Novel Bead-Based Biological Barcode Assay

10月 11th, 2016 / Hilary Graham

Enabling large-scale screening of small-molecule libraries in pooled cancer cell lines to discover genotype-specific vulnerabilities

Barcoding is no longer confined to the black stripes of the ubiquitous Universal Product Code (UPC) label found on nearly every product we purchase. Conservationist Paul Hebert was the first to demonstrate the feasibility and utility of DNA barcoding as a way to identify species in 2003.

Applications outside the research lab include the detection of food fraud, where lower quality fish is substituted for a more desirable species. A recent study by OCEANA found that 39 percent of 142 seafood samples collected and DNA tested from grocery stores, restaurants, and sushi venues in New York City were mislabeled.

Continue reading »

PiSCES Reveals More Than Your Horoscope

10月 11th, 2016 / Hilary Graham

Novel multiplex matrix network analysis method for the elucidation of protein-protein interaction signatures

While the genome is the molecular recipe, the proteome provides a glimpse into what is happening in real time. Like letters that join together to compose ‘words’, individual proteins can bind to form distinctive protein complexes, where the unique composition of each protein complex signals to the cell a specific message. The human genome was sequenced in 2003, but the different combinations that proteins can form remain largely uncharted due to technological limitations.

Although detecting the subtle changes in the proteome is no easy task, the lab of Adam Schrum was up for the challenge. Schrum and colleagues recently published an article in Science Signaling detailing the development of a new method, PiSCES (Proteins in Shared Complexes Detected by Exposed Surface Epitopes), capable of deciphering the molecular signatures unique to healthy and aberrant signaling networks associated with disease.

Continue reading »

Preparing for a Polio-Free World

3月 21st, 2017 / Hilary Graham

Supporting the development of new tests to assess mucosal immunity against polio To date, smallpox is the only

Continue reading »

DigiWest®: Reimaging Western Blotting on the Proteomic Scale

10月 11th, 2016 / Hilary Graham

A novel high-throughput protein analysis approach utilizing a bead-based microarray platform

The Western blot has been a staple in the molecular biology tool kit for nearly 40 years. While at Stanford, George Stark was the first to describe the transfer of proteins by capillary action from a gel onto diazobenzyloxymethyl-paper, submitting his work to the Proceedings of the National Academy of Sciences (PNAS) in April 1979.

Continue reading »