Guava® Nexin Reagent

Optimized for ease of use and deeper, faster scientific insights

 

The Guava® Nexin Reagent – 500 Tests (Part Number: 4500-0455) offers a simple, reproducible, and sensitive assessment of early apoptosis.

 

The Guava Nexin Reagent is a mix-and-read assay for monitoring externalization of phosphatidylserine (PS) through the binding of Annexin V to the exposed PS. Annexin V is a calcium-dependent phospholipid-binding protein with high affinity for phosphatidylserine (PS)—a membrane component normally localized to the internal side of the cell membrane. Early in the apoptotic pathway, molecules of PS are translocated to the outer surface of the cell membrane where Annexin V can readily bind to them.

 

The assay relies on a two-dye strategy:

 

  1. Annexin V-PE, which binds to PS on the external membrane of apoptotic cells
  2. 7-AAD, a fluorescent DNA intercalator that is membrane impermeant and is therefore excluded from live, healthy, and early apoptotic cells, but permeates late-stage apoptotic and dead cells

 

Product Information

 

Detection Method:

 

Fluorescence

 

Instrument Compatibility:

 

 

For Research Use Only. Not for use in diagnostic procedures.

Documentation is coming soon. Need Service or Support? Contact Support

 

Product

 

Guava® Nexin Reagent – 500 Tests

 

Part Number

 

4500-0455

 

Ordering Information

 

Ordering information can be found here

 

The following details will need to be included with your purchase orders in order to process them:

  • Company name
  • Name, phone number, and email address of purchasing agent
  • Name and phone number of the end user
  • Valid purchase order number
  • Quote reference number, where applicable
  • Complete billing and shipping addresses
  • Product number, description, pricing, and quantity
  • Net 30 payment terms or other agreed upon payment terms
  • FOB shipping point or other agreed upon shipping terms

 

Questions on Orders: [email protected].

 

Questions on Billing and Payments: [email protected].

 

For Research Use Only. Not for use in diagnostic procedures.