The ARIES® HSV 1&2 Assay is a rapid molecular method for the detection and differentiation of Herpes Simplex Virus 1 and 2 (HSV 1 and 2) in cutaneous or mucocutaneous lesion specimens and cerebrospinal fluid (CSF) using a sample to answer platform.*
Key features of this assay include:
HSV 1 and HSV 2 are common human pathogens that cause incurable infections in neonates, children and adults worldwide. Combined, HSV infections affect half a billion people between the ages of 15-49 years globally.1 HSV 1 is generally associated with infections in the tongue, mouth, lips, pharynx, and eyes, whereas HSV 2 is primarily associated with genital and neonate infections.
Viral isolation, direct or indirect fluorescent antibody testing, in situ hybridization, and serology can be used to diagnose HSV infections.2 However, due to the length of culture time, sample transport difficulties, procedural complexity, and a lack of desirable sensitivity, nucleic acid amplification methods such as PCR are often preferred as the diagnostic test method.3, 4
The reference/comparative method used to evaluate the clinical performance of the ARIES® HSV 1&2 Assay was ELVIS® HSV-ID and D3 Typing Test System.
|Summary of HSV 1 and 2 Results for Cutaneous Lesions|
|ARIES® HSV 1&2 Assay||Reference Method|
|HSV 1||95% CI|
|Summary of HSV 1 and 2 Results for Mucocutaneous Lesions|
|ARIES® HSV 1&2 Assay||Reference Method|
|HSV 1||95% CI|
Click here to view the clinical performance of the ARIES® HSV 1&2 Assay with Cerebrospinal Fluid (CSF).
Please see package insert for more detailed information.
The four-step work flow reduces the amount of hands-on time required to perform molecular testing. ARIES® cassettes are pre-loaded with all of the sample processing reagents needed. Simply add the sample to the side cassette, load the cassettes into the magazine, load the magazine into the instrument, and a run will start automatically.
|Luminex Online Order Management|
|Phone:||+31 (0)73 800 1900|
|Fax:||+31 (0)73 800 1998|
|Product Name||Kit Size||Registration Status||Part Number|
|ARIES® HSV 1&2 Assay||24 tests||CE Marked||50-10031|
|ARIES® HSV 1&2 Assay Protocol File Kit
(one time order only)
|ARIES® Two Module System
|1 unit||CE Marked||ARIES-M12V1-IVD|
|ARIES® M1 System
|1 unit||CE Marked||ARIES-M6V1-IVD|
|SYNCT™ Software||CE Marked||CN-SW47|
|ARIES® HSV 1&2 Assay Resources|
|ARIES® HSV 1&2 Assay (CE Marked)|
|ARIES®—Welcome to the New Way to Work (IVD)|
|ARIES® M1—Welcome to the New Way to Work (IVD)|
|Posters — Research Use Only†|
|Validation of ARIES® HSV 1 and 2 Using Formalin-Fixed Paraffin-Embedded Tissue|
|Comparison of Two Multiplex Molecular Assays for the Detection of Herpes Simplex 1 and 2 and Varicella Zoster Virus|
|Posters — In Vitro Diagnostics|
|MultiCenter Evaluation of the ARIES® HSV 1&2 Assay for Direct Detection of Herpes Simplex Virus Types 1 and 2 from Unprocessed Cutaneous and Mucosal Specimens|
|Comparison of Luminex® ARIES® HSV 1&2 Assay and Viral Culture for Laboratory Detection of Neonatal HSV Infection from Mucosal Swab Specimens|
|Workflow Study of Multi-Platforms vs Single Platform Testing of Routine Clinical Molecular Assays|
|Comparison of ARIES® HSV 1&2 Assay, Simplexa™ HSV 1 & 2 Direct and a Real-Time PCR Lab Developed Test for the Detection of HSV from Lesions|
|Comparative Evaluation of Three Automated Platforms for the Detection of Herpes Simplex Virus in Clinical Specimens|
|Comparison of Three Assays for HSV 1 and HSV 2 Detection: A Look at Focus Diagnostics 3M Integrated Cycler, Luminex ARIES® System, and Roche Lightcyler® 2.0|
|Evaluation of ARIES® HSV 1&2 and Simplexa™ HSV 1&2 Direct Assays for the Detection and Differentiation of Herpes Simplex Virus from Cerebrospinal Fluid and Swab Specimens|
|Diagnosis of Disseminated HSV Infection Using Plasma Samples on the ARIES Sample-to-Answer HSV 1&2 PCR Assay|
|Performance Comparison and Workflow Evaluation of Simplexa™ HSV 1&2 Direct and ARIES® HSV 1&2 Assay for the Detection of HSV 1&2 in Genital and Non-genital Specimens|
|Detection of Herpes Simplex Virus by Three Nucleic Acid Amplification Methods and the ELVIS ID System|
|Brochures & White Papers|
|ARIES® M1 Brochure – Welcome to the New Way to Work|
|ARIES® Lean Lab White Paper: Delivering More with Less|
For In Vitro Diagnostic Use. Products are region specific and may not be approved in some countries/regions. Please contact Luminex at [email protected] to obtain the appropriate product information for your country of residence.
* Intended Use (CE Marked)
The ARIES® HSV 1&2 Assay is a real-time polymerase chain reaction (PCR) based qualitative in vitro diagnostic test for the direct detection and typing of herpes simplex virus (HSV 1 and 2) DNA in cutaneous or mucocutaneous lesion specimens from symptomatic patients or in CSF from patients suspected of HSV infections of the central nervous system (CNS). The test is indicated for use with symptomatic individuals to aid in the diagnosis of HSV infections.
Negative CSF results do not preclude HSV 1 and HSV 2 infection and should not be used as the sole basis for diagnosis, treatment, or other patient management decisions.
The assay is not intended to be used for prenatal screening.
The ARIES® HSV 1&2 Assay (EU) is indicated for use on the ARIES® Systems.
ARIES® Systems are class 1(I) laser products.
Validation of the LIS compatibility must be performed by the end user.
† These products are for Research Use Only. Not for use in diagnostic procedures. Please contact Luminex at [email protected] to obtain the appropriate product information for your country of residence.