METHODS Special Issue: Multiplexing Protocol for Evaluating Biological Interactions with Nanoparticles

A new multiplexing protocol offers guidelines for measuring immunomodulatory effects of nanoparticles used in clinical applications Nanoparticles have the potential to deliver more targeted therapies to the exact location in the body where they’re most needed. To do this, it is essential to understand how these foreign particles interact with a patient’s body. A recent […]

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METHODS Special Issue: Multiplexing for Personalized Oncology

Assays quantify RNA expression even in challenging samples Multiplex molecular assays have several important roles in the realm of personalized cancer medicine. A team of researchers at the University of Malta recently published a paper, titled “Bead-based RNA multiplex panels for biomarker detection in oncology samples,” in the Methods journal that offers an overview of […]

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Webinar: Improving Rheumatoid Arthritis Diagnostics with Multiplex Assays

How a European team avoided performing 16,000 ELISA tests New efforts to improve the diagnosis of rheumatoid arthritis, as well as to guide treatment selection, are making strong progress thanks to xMAP® Technology from Luminex, according to a recent presentation from Erik Lönnblom of the Karolinska Institute. Multiplex immunoassays have allowed his team and collaborators […]

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METHODS Special Issue: Multiplexing to Quantify Cytokines and Chemokines in Mouse Brain Study

Assay requires minimal sample volume for 33-analyte interrogation Scientists from the National Institute of Neurological Disorders and Stroke and Bio-Rad Laboratories published a helpful protocol for a method to analyze more than 30 cytokines and chemokines in mouse brain tissue. The technique can be adapted to other sample types as well. The paper, titled “Method […]

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METHODS Special Issue: Clinical and Analytical Performance Data for NxTAG RPP

Highly scalable, multiplex molecular assay is comparable to xTAG RVP performance If you’ve ever used an assay based on xTAG® Technology, you may wonder how the newer NxTAG® Chemistry stacks up. A new publication in Methods uses clinical and analytical data from respiratory pathogen panels to demonstrate how both performance and workflow have improved with […]

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METHODS Special Issue: New Multiplex Assay for Vaccine Immunogenicity Testing

Recently developed test lowers cost and reduces sample volumes needed for evaluating combination vaccines Scientists at the Serum Institute of India have developed a new multiplex immunoassay to perform the mouse immunogenicity testing recommended in many countries for quality control in the production of combination vaccines. They chose xMAP® Technology to design the serological assay, […]

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METHODS Special Issue: Multiplexing Enables More Robust Surveillance for Avian Influenza

New assay developed for routine poultry monitoring In the journal Methods, scientists from Wageningen Bioveterinary Research report the development of a multiplex assay for avian influenza. The assay is built on Luminex’s xMAP® Technology, and allows for serotyping all 16 hemagglutinin (HA) and 9 neuraminidase (NA) protein subtypes simultaneously. Testing for avian influenza (AI) is […]

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METHODS Special Issue: New Assays to Characterize Vaccination and Infection History

Single-plex targets developed will become components for future multiplex assays Scientists in the Waterboer lab at the German Cancer Institute have developed the building blocks for a multiplex assay that will make it possible to quickly interrogate a person’s history of infection and vaccination. In a paper from Methods, the team reports developing individual assays […]

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Webinar: Protein Conformational Analysis Goes High-Throughput with xMAP Technology

Technique provides critical data for development of monoclonal antibodies and biosimilars At a 2018 xMAP® Connect user group meeting, Xing Wang, President of Array Bridge, spoke about how his team is using xMAP Technology to streamline the development of new biologics and biosimilars for pharma/biotech scientists. The 30-minute presentation focuses on protein conformational analysis (PCA), […]

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METHODS Special Issue: A Universal Protocol for Attaching Any Peptide to Dyed Magnetic Beads

A new technique eliminates the use of monoclonal antibodies and is robust enough for field use Monoclonal antibodies may soon become a thing of the past. While their high selectivity and affinity for their targets once made them the “gold standard” for detection applications, the time it takes to generate one and the variability in […]

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