NFAT (Human)
| Description | Four closely related forms of NFAT (NFATp, NFATc, NFAT3, NFATx) and a fifth more distantly related form (NFAT5) have been identified. NFAT proteins regulate gene expression in diverse cell types; macrophages, mast cells, eosinophils, skeletal and smooth muscle cells, vascular endothelial cells, pancreatic islet cells, adipocytes and T-cells. In T-cells, NFAT is activated in response to T-cell activation by TPA and ionomycin. In response to changes in intracellular calcium levels, particular isoforms of NFAT are dephosphorylated by calcineurin to expose nuclear localization signals. Translocated NFAT in many cases can interact directly with AP1 and activate transcription synergistically with other transcription factors such as EGR-1, Oct, IRF-4, and C/EBP. |
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| Partners | Affymetrix OriGene Technologies |
