xTAG® CYP2D6
Empowering Personalized Medicine
The CYP2D6 gene belongs to the cytochrome P450 gene family, a group of enzymes responsible for metabolism of many classes of drugs and other foreign compounds.
xTAG CYP2D6 Overview
A wide variety of clinically significant drugs including ß-blockers, antipsychotics, antidepressants, analgesics, anti cancer and antiarrythmics are substrates for the CYP2D6 pathway. Owing to the fact that this gene is highly polymorphic across the human population, an individual’s specific allele combination can result in distinct drug metabolizing phenotypes for the various drugs and consequently the potential for different drug responses. Additionally, co-administration of drugs that act as inducers or inhibitors of CYP2D6 can also affect drug metabolizing phenotypes. These, along with other lifestyle and physiological factors, including the individual’s age, size and gender, renal and liver function, disease status, can result in varying CYP2D6 metabolism phenotypes.
The xTAG CYP2D6 assay is a comprehensive, accurate, and easy to use test that can detect polymorphisms associated with drug metabolism across diverse populations and is to be used as an aid in determining therapeutic strategy for therapeutics that are metabolized by the CYP2D6 gene product. This test is not indicated for stand-alone diagnostic purposes.
For In Vitro Diagnostic Use. Products are region specific and may not be approved in some countries/regions. Please contact Luminex at support@luminexcorp.com to obtain the appropriate product information for your country of residence.
xTAG CYP2D6 Product Description
The xTAG CYP2D6 Kit v3 simultaneously detects and identifies a panel of nucleotide variants found within the highly polymorphic CYP2D6 gene. It also identifies gene rearrangements associated with the deletion (*5) and duplication genotypes.
Mutations and Polymorphisms Detected by the xTAG CYP2D6 Kit v3
| Star (*) Genotype | Mutations and Polymorphisms† (detected by xTAG CYP2D6) | |
|---|---|---|
| PCR A | PCR B | |
| *1 | None | None |
| *2 | -1584C>G, 1661G>C | 2850C>T, 4180G>C |
| *3 | – | 2549A>del |
| *4 | 100C>T, 1661G>C, 1846G>A | 2850C>T, 4180G>C |
| *5 | – | Deletion |
| *6 | 1707T>del | 4180G>C |
| *7 | – | 2935A>C |
| *8 | 1661G>C, 1758G>T | 2850C>T, 4180G>C |
| *9 | – | 2613delAGA |
| *10 | 100C>T | 1661G>C, 4180G>C |
| *11 | 883G>C, 1661G>C | 2850C>T, 4180G>C |
| *15 | 138insT | – |
| *17 | 1023C>T, 1661G>C | 2850C>T, 4180G>C |
| *29 | 1659G>A, 1661G>C | 2850C>T, 3183G>A, 4180G>C |
| *35 | -1584C>G, 31G>A, 1661G>C | 2850C>T, 4180G>C |
| *4 | 1661G>C | 2850C>T, 2988G>A, 4180G>C |
| DUP | Duplication | – |
| † Nucleotide changes that define the star (*) genotype are shown in bold font | ||
Predicted Enzyme Activity with xTAG CYP2D6 Kit v3 SNPs
| Final TDAS Output (* genotype or * allele) |
SNPs detected by xTAG CYP2D6 v3 Kit | Predicted Enzyme Activity |
|---|---|---|
| *1 | None | Normal |
| *2 | -1584C>G, 1661G>C, 2850C>T, 4180G>C | Normal |
| *3 | 2549A>del | None |
| *4 | 100C>T, 1661G>C, 1846G>A, 4180G>C, 2850C>T | None |
| *5 | deletion | None |
| *6 | 1707T>del, 4180G>C | None |
| *7 | 2935A>C | None |
| *8 | 1661G>C, 1758G>T, 2850C>T, 4180G>C | None |
| *9 | 2613delAGA | Reduced |
| *10 | 100C>T, 1661G>C, 4180G>C | Reduced |
| *11 | 883G>C, 1661G>C, 2850C>T, 4180G>C | None |
| *15 | 38insT | None |
| *17 | 1023C>T, 1661G>C, 2850C>T, 4180G>C | Reduced |
| *29 | 1659G>A, 1661G>C, 2850C>T, 3183G>A, 4180G>C |
Reduced |
| *35 | -1584C>G, 31G>A, 1661G>C, 2850C>T, 4180G>C | Normal |
| *41 | 1661G>C, 2850C>T, 2988G>A, 4180G>C | Reduced |
| Data gathered from: Bradford 2002; Wennerholm, Johansson et al. 2001 ; Gaedigk, Ryder et al. 2003 | ||
Key Benefits
- Comprehensive: Comprehensive allele coverage, including gene deletion and gene duplication genotypes.
- Confidence: IVD assay with 100% overall reproducibility (after allowable re-runs) and 99.6% overall accuracy.
- Ease of Use: Streamlined protocol providing same day results with automated star genotyping call software.
- Cost-effective: Multiplex genotyping, fast turn around time, all ancillary reagents and enzymes included.
For In Vitro Diagnostic Use. Products are region specific and may not be approved in some countries/regions. Please contact Luminex at support@luminexcorp.com to obtain the appropriate product information for your country of residence.
xTAG CYP2D6 Workflow: Extracted Sample to Result in Less Than Eight Hours
For In Vitro Diagnostic Use. Products are region specific and may not be approved in some countries/regions. Please contact Luminex at support@luminexcorp.com to obtain the appropriate product information for your country of residence.
Downloads
| Document | Language | Type | Download |
|---|---|---|---|
| MSDS |
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| MSDS (click to search database) | |||
| Brochure | |||
| xMAP CYP2D6 Overview | English | pdf  |
 |
For In Vitro Diagnostic Use. Products are region specific and may not be approved in some countries/regions. Please contact Luminex at support@luminexcorp.com to obtain the appropriate product information for your country of residence.
CYP2D6 Training Course
| Course Title | Format | Duration |
|---|---|---|
| xTAG CYP2D6 v3 IVD Onsite Assay Kit Training | Customer Lab | 2.5 days |
For In Vitro Diagnostic Use. Products are region specific and may not be approved in some countries/regions. Please contact Luminex at support@luminexcorp.com to obtain the appropriate product information for your country of residence.
Support Information
Luminex offers comprehensive technical support enabling companies and laboratories to perform clinical diagnosis quickly, accurately, and cost effectively while optimizing the customer experience with Luminex assays and systems.
| Support Resources | Technical Support | Field Service | ||
|---|---|---|---|---|
| Target Values | Online Support Login | Certified Service Providers | ||
| Email: support@luminexcorp.com | Maintenance and Support | |||
| Phone: 512-381-4397 | Luminex Central Repair Facility | |||
| Toll Free: 1-877-785-2323 | ||||
| International: + 800-2939-4959 |
For In Vitro Diagnostic Use. Products are region specific and may not be approved in some countries/regions. Please contact Luminex at support@luminexcorp.com to obtain the appropriate product information for your country of residence.
Ordering Information
| Luminex Direct | Luminex Partners |
|---|---|
| Luminex Online Order Management Email: orders@luminexcorp.com Phone: 1-512-336-3550 Toll Free: 1-866-401-5450 Fax: 1-512-219-0544 Fax: 31-162-408330 (EMEA, India) |
Luminex Partners List |
| Product Name | Kit Size | Registration Status | Catalog Number | Available from |
|---|---|---|---|---|
| xTAG CYP2D6 Kit v3 | 48 | IVD-US | I030B0373 | Luminex |
| xTAG CYP2D6 Kit v3 | 48 | CE-IVD Marked | I030B0374 | Luminex |
For In Vitro Diagnostic Use. Products are region specific and may not be approved in some countries/regions. Please contact Luminex at support@luminexcorp.com to obtain the appropriate product information for your country of residence.