Transcription Factors/Nuclear Receptors

Description
Gene expression is regulated via proteins called transcription factors and nuclear receptors that bind to specific regulatory sequences in DNA, thereby modulating the transcription of genes into RNA. These proteins are often present in the cell in an inactive form, and only become activated to bind to their cognate recognition sequences as a result of a specific signal transduction event. xMAP® Technology provides a powerful approach for multiplex detection of activated transcription factors, allowing researchers to simultaneously measure the binding of many different transcription factors at once in a single sample. Results can be obtained in a few hours, allowing hundreds of samples to be analyzed in a day. Excellent sensitivity, dynamic range and reproducibility are routinely achieved. Such assays are appropriate for research in many scientific disciplines, providing a powerful technology for elucidating mechanisms of gene regulation, identifying drug targets, screening lead compounds and proteomics research.

Tests available from:

 Analytes
AP-1 General 
AP-2 General 
AR General 
ATF2 General 
BRN3 General 
C-MYB General 
CEBP General 
CRE-ATF1 General 
CREB General 
E2F1 General 
E2F1-5 General 
E2F6 General 
EGR Human  General 
ELK1 General 
ER General 
ETS/PEA General 
FAST1 General 
FKHR-1 General 
GATA General 
GR/PR General 
HIF-1 Human 
HNF1 General 
HNF4 General 
IRF1 General 
ISRE General 
MEF-2 General 
Myc-Max General 
MYOD General 
NF-1 Human  General 
NF-E1(YY1) General 
NF-E2 General 
NF-Y General 
NFAT Human 
NFkB General 
NFkB Gene Family Human 
NKX-2.5 General 
OCT General 
p53 General 
PAX3 General 
PAX5 General 
PPAR Human  General 
RUNX/AML General 
SMAD General 
SMAD 2/3 General 
SP1 General 
SRE Human 
STAT1 General 
STAT3 General 
STAT4 General 
STAT5 General 
YY1 Human  General

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